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May 30, 2013 ? Researchers at The Open University (OU) and The University of Manchester have found conclusive proof that Ancient Egyptians used meteorites to make symbolic accessories for their dead.
The evidence comes from strings of iron beads which were excavated in 1911 at the Gerzeh cemetery, a burial site approximately 70km south of Cairo. Dating from 3350 to 3600 BC, thousands of years before Egypt's Iron Age, the bead analysed was originally assumed to be from a meteorite owing to its composition of nickel-rich iron. But this hypothesis was challenged in the 1980s when academics proposed that much of the early worldwide examples of iron use originally thought to be of meteorite-origin were actually early smelting attempts.
Subsequently, the Gerzeh bead, still the earliest discovered use of iron by the Egyptians, was loaned by The Manchester Museum to the OU and Manchester's School of Materials for further testing. Researchers used a combination of the OU's electron microscope and the University's X-Ray CT scanner to demonstrate that the nickel-rich chemical composition of the bead confirms its meteorite origins.
OU Project Officer Diane Johnson, who led the study, said: "This research highlights the application of modern technology to ancient materials not only to understand meteorites better but also to help us understand what ancient cultures considered these materials to be and the importance they placed upon them."
Meteorite iron had profound implications for the Ancient Egyptians, both in their perception of the iron in the context of its celestial origin and in early metallurgy attempts.
Dr Joyce Tyldesley is a Senior Lecturer in Egyptology at The University of Manchester and worked on the research. She said: "Today, we see iron first and foremost as a practical, rather dull metal. To the ancient Egyptians, however, it was a rare and beautiful material which, as it fell from the sky, surely had some magical/religious properties. They therefore used this remarkable metal to create small objects of beauty and religious significance which were so important to them that they chose to include them in their graves."
Philip Withers, Professor of Materials Science at The University of Manchester, added: "Meteorites have a unique microstructural and chemical fingerprint because they cooled incredibly slowly as they travelled through space. It was really interesting to find that fingerprint turn up in Egyptian artefacts."
The results of the study of the bead can be obtained in the paper, 'Analysis of a Prehistoric Egyptian Iron Bead with Implications for the use and perception of meteorite iron in ancient Egypt.' published in the Meteoritics and Planetary Science journal.
Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_science/~3/Xzz9VELUbbA/130530094635.htm
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May 29, 2013 ? During the last ice age, when thick ice covered the Arctic, many scientists assumed that the deep currents below that feed the North Atlantic Ocean and help drive global ocean currents slowed or even stopped. But in a new study in Nature, researchers show that the deep Arctic Ocean has been churning briskly for the last 35,000 years, through the chill of the last ice age and warmth of modern times, suggesting that at least one arm of the system of global ocean currents that move heat around the planet has behaved similarly under vastly different climates.
"The Arctic Ocean must have been flushed at approximately the same rate it is today regardless of how different things were at the surface," said study co-author Jerry McManus, a geochemist at Columbia University's Lamont-Doherty Earth Observatory.
Researchers reconstructed Arctic circulation through deep time by measuring radioactive trace elements buried in sediments on the Arctic seafloor. Uranium eroded from the continents and delivered to the ocean by rivers, decays into sister elements thorium and protactinium. Thorium and protactinium eventually attach to particles falling through the water and wind up in mud at the bottom. By comparing expected ratios of thorium and protactinium in those ocean sediments to observed amounts, the authors showed that protactinium was being swept out of the Arctic before it could settle to the ocean bottom. From the amount of missing protactinium, scientists can infer how quickly the overlying water must have been flushed at the time the sediments were accumulating.
"The water couldn't have been stagnant, because we see the export of protactinium," said the study's lead author, Sharon Hoffmann, a geochemist at Lamont-Doherty.
The upper part of the modern Arctic Ocean is flushed by North Atlantic currents while the Arctic's deep basins are flushed by salty currents formed during sea ice formation at the surface. "The study shows that both mechanisms must have been active from the height of glaciation until now," said Robert Newton, an oceanographer at Lamont-Doherty who was not involved in the research. "There must have been significant melt-back of sea ice each summer even at the height of the last ice age to have sea ice formation on the shelves each year. This will be a surprise to many Arctic researchers who believe deep water formation shuts down during glaciations."
The researchers analyzed sediment cores collected during the U.S.-Canada Arctic Ocean Section cruise in 1994, a major Arctic research expedition that involved several Lamont-Doherty scientists. In each location, the cores showed that protactinium has been lower than expected for at least the past 35,000 years. By sampling cores from a range of depths, including the bottom of the Arctic deep basins, the researchers show that even the deepest waters were being flushed out at about the same rate as in the modern Arctic.
The only deep exit from the Arctic is through Fram Strait, which divides Greenland and Norway's Svalbard islands. The deep waters of the modern Arctic flow into the North Atlantic via the Nordic seas, contributing up to 40 percent of the water that becomes North Atlantic Deep Water -- known as the "ocean's lungs" for delivering oxygen and salt to the rest of world's oceans.
One direction for future research is to find out where the missing Arctic protactinium of the past ended up. "It's somewhere," said McManus. "All the protactinium in the ocean is buried in ocean sediments. If it's not buried in one place, it's buried in another. Our evidence suggests it's leaving the Arctic but we think it's unlikely to get very far before being removed."
Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_science/~3/LZjcwK_aOAE/130529133456.htm
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Abdul-Baki Todashev holds a photo he claims is of his dead son Ibragim Todashev, during a news conference in Moscow, Russia, Thursday, May 30, 2013. The father of a Chechen immigrant killed in Florida while being interrogated by the FBI about his ties to a Boston Marathon bombings suspect says agents killed his son ?execution style.? Abdul-Baki Todashev showed journalists 16 photographs on Thursday of his son, Ibragim, in the morgue with what he said were six gunshot wounds to his torso and one to the back of the head. He said the pictures were taken by his son?s friend Khusen Taramov. (AP Photo/Alexander Zemlianichenko)
Abdul-Baki Todashev holds a photo he claims is of his dead son Ibragim Todashev, during a news conference in Moscow, Russia, Thursday, May 30, 2013. The father of a Chechen immigrant killed in Florida while being interrogated by the FBI about his ties to a Boston Marathon bombings suspect says agents killed his son ?execution style.? Abdul-Baki Todashev showed journalists 16 photographs on Thursday of his son, Ibragim, in the morgue with what he said were six gunshot wounds to his torso and one to the back of the head. He said the pictures were taken by his son?s friend Khusen Taramov. (AP Photo/Alexander Zemlianichenko)
Abdul-Baki Todashev holds a photo he claims is of his dead son Ibragim Todashev, during a news conference in Moscow, Russia, Thursday, May 30, 2013. The father of a Chechen immigrant killed in Florida while being interrogated by the FBI about his ties to a Boston Marathon bombings suspect says agents killed his son ?execution style.? Abdul-Baki Todashev showed journalists 16 photographs on Thursday of his son, Ibragim, in the morgue with what he said were six gunshot wounds to his torso and one to the back of the head. He said the pictures were taken by his son?s friend Khusen Taramov. (AP Photo/Alexander Zemlianichenko)
Abdul-Baki Todashev holds a photo he claims is of his dead son Ibragim Todashev during a news conference in Moscow, Russia, Thursday, May 30, 2013. The father of a Chechen immigrant killed in Florida while being interrogated by the FBI about his ties to a Boston Marathon bombings suspect says agents killed his son ?execution style.? Abdul-Baki Todashev showed journalists 16 photographs on Thursday of his son, Ibragim, in the morgue with what he said were six gunshot wounds to his torso and one to the back of the head. He said the pictures were taken by his son?s friend Khusen Taramov. (AP Photo/Alexander Zemlianichenko)
Abdul-Baki Todashev holds a photo he claims is of his dead son Ibragim Todashev, during a news conference in Moscow, Russia, Thursday, May 30, 2013. The father of a Chechen immigrant killed in Florida while being interrogated by the FBI about his ties to a Boston Marathon bombings suspect says agents killed his son ?execution style.? Abdul-Baki Todashev showed journalists 16 photographs on Thursday of his son, Ibragim, in the morgue with what he said were six gunshot wounds to his torso and one to the back of the head. He said the pictures were taken by his son?s friend Khusen Taramov. (AP Photo/Alexander Zemlianichenko)
MOSCOW (AP) ? The father of a Chechen immigrant killed in Florida while being interrogated by the FBI about his ties to a Boston Marathon bombings suspect said Thursday that the U.S. agents killed his son "execution-style."
At news conference in Moscow, Abdul-Baki Todashev showed journalists 16 photographs that he said were of his son, Ibragim, in a Florida morgue. He said his son had six gunshot wounds to his torso and one to the back of his head and the pictures were taken by his son's friend, Khusen Taramov.
It was not immediately possible to authenticate the photographs.
The FBI says 27-year-old mixed martial arts fighter Ibragim Todashev was killed last week during a violent confrontation in his Orlando home while an FBI agent and two Massachusetts state troopers questioned him about his ties to slain Boston Marathon bombing suspect Tamerlan Tsarnaev, as well as about a 2011 triple slaying in Massachusetts.
Three law enforcement officials said initially that Todashev had lunged at the FBI agent with a knife, although two of them later said it was no longer clear what had happened.
Greg Comcowich, a spokesman for the Boston FBI, declined to comment Thursday on the elder Todashev's claim that his son was unarmed.
Abdul-Baki Todashev said the photos were emailed to him by Taramov, who apparently was at the morgue to identify the body. The father said Taramov was part of the Muslim community holding the body for the family until they could retrieve it.
The father said Taramov told him that U.S. agents interrogated him on the street while five officials interrogated Todashev in his Florida house for eight hours on May 22, the night he was shot. He said his son was "100 percent unarmed."
Todashev's father said his son moved to the U.S. in 2008 on a study exchange program and met Tsarnaev at a boxing gym in Boston in 2011, about a year before he moved to Orlando. He said the two were "not particularly close friends."
Prior to last month's bombings, Todashev underwent an operation for a sports injury and was on crutches, making it physically impossible for him to have been involved in the bombings, his father said. He added that Todashev had recently received a green card and was planning to return to Chechnya for the summer last Friday, two days after he was killed.
The father said he and his brother were interviewed at the U.S. Embassy in Moscow on Thursday as they sought a visa to take his son's body back to Chechnya.
FBI agents interrogated the younger Todashev twice before the night he was shot, his father said. Todashev told him that he thought Tsarnaev had been set up to take blame for the bombings.
"I'd only seen and heard things like that in the movies ? they shoot somebody and then a shot in the head to make sure," Todashev said.
"These just aren't FBI agents, they're bandits," he added.
___
Associated Press writer Denise Lavoie in Boston contributed to the story.
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Posted on: 2:57 pm, May 29, 2013, by George Brown and Adam Hammond, updated on: 04:30pm, May 29, 2013
(Memphis) Members of the budget and finance committee for the Shelby County Commission have approved an extra $20 million for the merged school district.
The committee also approved adding six-cents to the property tax.
That is on top of the 30-cent property tax increase to make up for the decline in property values.
This was the first of three readings.
If the tax hikes are approved, the property tax would be $4.38.
?
(Memphis) You are one step closer to paying higher property taxes, and it?s all for the sake of unified schools.
Members of the budget and finance committee for the Shelby County Commission have approved an extra $20 million for the merged school district.
The only problem is they had to come up with that $20 million, and they did it by voting to raise your tax rate.
Under Mayor Luttrell?s new plan the tax rate in most of Shelby County is 4.38.
That?s up from the current rate 4.02.
?We would not recommend keeping the tax rate at 4.02 because that would not allow us to have enough money to carry out the responsibility for schools,? said Mayor Luttrell?s administration.
Last week, Luttrell raised the rate to get the same amount of money as last year, since property values are down, causing the county to get less money.
Most of your property values went down around 10%.
Wednesday they asked for 6 cents to be added to that to collect a total of $20 Million for the unified school district and they got it.
?The budget resolution needs more money for the schools so I think we need to keep them inline as we move down the road,? said Commissioner Mike Ritz.
Not everyone was so agreeable on the first reading.
Commissioner Wyatt Bunker says this move will drive business out of the county.
?Do you think anyone said ?hey I?d much rather go set up my business in Shelby County instead of Desoto County because I get a higher cost of doing business??
Commissioner Terry Roland has an even bleaker outlook, ?In five years when we?re Detroit they?re going to care. Because everyone who can leave will leave.?
This is the first reading and it takes three to raise the property tax rate.
The commission will meet again Monday where they will take the issue up once again.
Source: http://wreg.com/2013/05/29/county-commission-committee-approves-extra-money-for-schools-tax-hike/
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FILE - In this Sept. 4, 2012 file photo, Rhode Island Gov. Lincoln Chafee addresses the Democratic National Convention in Charlotte, N.C. Chafee, an independent, is joining the Democratic Party ahead of his bid for a second term, two Democratic officials said Thursday, May 29, 2013. He served in the U.S. Senate as a Republican but left the GOP in 2007. (AP Photo/J. Scott Applewhite, File)
FILE - In this Sept. 4, 2012 file photo, Rhode Island Gov. Lincoln Chafee addresses the Democratic National Convention in Charlotte, N.C. Chafee, an independent, is joining the Democratic Party ahead of his bid for a second term, two Democratic officials said Thursday, May 29, 2013. He served in the U.S. Senate as a Republican but left the GOP in 2007. (AP Photo/J. Scott Applewhite, File)
FILE - In this May 29, 2012 file photo, Rhode Island Gov. Lincoln Chafee speaks at the Statehouse in Providence, R.I. Chafee, an independent, is joining the Democratic Party ahead of his bid for a second term, two Democratic officials said Thursday, May 29, 2013. He served in the U.S. Senate as a Republican but left the GOP in 2007. (AP Photo/Steven Senne, File)
NARRAGANSETT, R.I. (AP) ? Independent Rhode Island Gov. Lincoln Chafee is joining the Democratic Party ahead of his 2014 bid for a second term, his spokeswoman said Wednesday, confirming a move that Chafee has been talking about for months as a way to better position himself for re-election.
Chafee would not immediately address his party switch when asked about it Wednesday after he exited a ferry from Block Island to the mainland, saying only that he would announce his decision at his local board of canvassers in Warwick on Thursday morning. But he did say his priorities haven't changed.
"All I've cared about since my time in public service started is good, honest, efficient government. That hasn't changed. Nothing has changed since I was a councilman in Warwick," Chafee said.
The governor, a former Republican senator, became a political independent in 2007, the year after he lost re-election to the U.S. Senate. He was elected as the nation's only independent governor in 2010.
Chafee has noted in the past that he shares many positions with Democrats and that joining the party would help with fundraising. He is a supporter of President Barack Obama, who he endorsed ahead of the Democratic primary in 2008, and he spoke at last year's Democratic National Convention. But for local Democrats, the move complicates next year's gubernatorial primary and sets up the possibility of a three-way matchup with Providence Mayor Angel Taveras and Treasurer Gina Raimondo.
Obama said in a statement that he was delighted and thrilled by the decision. He called Chafee an "independent thinker and leader who's unafraid to reach across party lines to get things done" and said he looked forward to working with him in the years ahead. Vermont Gov. Peter Shumlin, chairman of the Democratic Governors Association, said the group was excited to welcome Chafee and looked forward to "enthusiastically supporting whoever emerges as the Democratic nominee in Rhode Island."
Many local Democrats declined to immediately weigh in, with some saying they hadn't been informed of Chafee's plan and others declining to comment. House Speaker Gordon Fox, the most powerful Democrat in state politics, had not been told of any plan by Chafee to switch parties, a spokesman for Fox said. Hours after news of the switch broke, Fox issued a statement saying he was pleased Chafee had joined Democrats' ranks and looked forward to talking about it with Chafee soon.
Taveras responded by highlighting his own party credentials, saying in a statement that he has been "a Democrat and a Red Sox fan my whole life, and I don't intend on changing either."
Raimondo said in a statement that Chafee's decision to switch parties a second time has not changed her thinking on a run for governor, which she said she is seriously considering.
"The question Rhode Islanders have is who can provide the leadership we need to move our state forward," she said.
Former longtime Democratic Congressman Patrick Kennedy told The Associated Press that the move makes sense for Chafee given his political views, including his support for Obama's health care overhaul and his longtime support for legalizing same-sex marriage, which he recently signed into law in Rhode Island. Kennedy said Chafee's views "put him in the mainstream of the Democratic Party."
"He has been very progressive in those ways and I think he'll find a lot of people embracing him, and I think welcoming him," Kennedy said, adding that it would be great to have him join the party.
Registered Democrats outnumber registered Republicans in Rhode Island more than three to one, although most voters aren't affiliated with any party.
When asked how he thinks local Democrats will react, given the likelihood that two longtime Democrats are already running for governor, Kennedy, who now lives in New Jersey, said Democrats know Chafee shares their core principles.
"He is the incumbent governor, and he has been a strong supporter of our incumbent president, and I think it would be important for us to acknowledge his support for the traditional principles of the Democratic Party. It's not like he's becoming a Democrat for political expediency alone. He's been consistent," Kennedy said.
Brown University political science Prof. Wendy Schiller said changing parties is a risky move for the governor, setting up a matchup with two of the state's most popular politicians with built-in bases of support.
Taveras is Hispanic and is likely to compete with Chafee for the support of organized labor. Raimondo could win over more conservative Democrats and tussle with Chafee for the party's female base.
"I still do not see the significant gain for Chafee in switching parties," Schiller said. "Raimondo and Taveras represent the future of the Democratic Party. They span a wide spectrum of Democratic voters. I think he'd really benefit if those two really beat each other up."
Schiller also downplayed the fundraising advantage to switching parties, saying his status as the nation's only independent governor gave him a distinction he will lose by becoming just another Northeast Democrat.
Although Rhode Island is heavily Democratic, it has not had a Democratic governor for years. Chafee will become the first Democrat to hold the seat since 1995.
Chafee is son of the late U.S. Sen. John Chafee, a former governor whose name was synonymous with the Republican Party in Rhode Island for decades. When John Chafee died in office in 1999, Lincoln Chafee was appointed to fill his seat, and then won re-election to the post the following year. In the Senate, he voted to the left of many Democrats, opposing the war in Iraq, for example. But he stuck it out as a Republican through his 2006 re-election campaign, which he lost to Whitehouse.
He left the party in 2007 and became an independent. He made his political comeback in 2010, winning a four-way race for governor with 36 percent of the vote.
As governor, Chafee has struggled with poor approval ratings and some of his policy proposals have fizzled in the face of opposition in the Democratic-controlled General Assembly, such as an early plan to expand the sales tax.
Chafee is a reluctant fundraiser, and he has often depended on personal wealth to fund his campaigns. He told the AP in December that he was considering joining the Democrats to help his chances of winning a second term.
___
Associated Press writers Michelle R. Smith in Providence and Ken Thomas and Darlene Superville in Washington contributed to this report.
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With Panasonic's new Viera E60 family of connected LED-backlit HDTVs you get many of the features found on high-end models at a price that won't strain your budget. The TC-L58E60 reviewed here carries a list price of $1,499.99 and features a large 58-inch screen with a 120Hz refresh rate, wired and wireless networking, a good selection of Web services, and a streamlined cabinet design. But it's not without flaws; greens and blues are oversaturated and there are traces of blooming when the background is dark.
Design and Features
As with the Editors' Choice Panasonic TC-L55ET60, the TC-L58E60's cabinet is stylishly thin (1.4 inches) and is ably supported by a rigid rectangular stand. The 1,920-by-1,080-pixel panel is framed by razor-thin black bezels on all sides, and there's a strip of clear plastic beneath the bottom bezel that holds an ambient light sensor, a remote sensor, and a power indicator.
The TC-L58E60 only has three HDMI ports, whereas most big-screen TVs offer at least four, and sometimes five. They are mounted at the rear of the cabinet facing outward along with a set of shared component and composite AV jacks, an Ethernet port, a digital audio output, and a cable/antenna jack. Two USB ports are close by, facing left.?A set of basic controls sit on the right edge of the screen.
In addition to wired Ethernet the E60 offers built-in Wi-Fi. Web services are plentiful and include streaming apps from Netflix, Amazon Instant Video, Hulu Plus, YouTube, and CinemaNow. Social networking apps, including Skype, Facebook, and Twitter, are also part of the package, as are a handful of Playjam games and Panasonic's own Viera Connect Market shopping service.
The E60 uses the same remote as the ET60 with one exception; a sleep button takes the place of a 3D button (this set is not 3D-capable). The matte black wand is 8.5 inches long and has 43 buttons, four arrow keys, an Apps button, and a dedicated Netflix button. The Home button brings you to the My Home screen where you can create customized menus for each member of the family by populating it with their favorite apps and photo, video, and music selections.
The basic picture settings menu offers the usual brightness, contrast, color temperature, tint, and backlight adjustments as well as Vivid Color (enhanced greens and blues), A.I. Picture (enhances dark areas without changing black level or brightness), and five picture presets (Vivid, Standard, Home Theater, Cinema, and Custom). The Pro settings menu lets you adjust black level gradation, fine tune white point levels in reds, greens, and blues, tweak RGB hue, saturation, and luminance levels, and adjust gamma settings. Advanced settings include an optimized game mode, 3:2 pulldown (reduces judder in film-based content), light and dark black levels, and HDMI range settings.
The TC-L58E60 comes with a standard one-year warranty that can be extended to three years for an additional $129.99, or to four years for an additional $169.99.
Performance
The TC-L58E60 performed well on some tests and not so well on others. It produced a nice peak brightness of 353.50 cd/m2 and a solid black level reading of 0.0137 cd/m2 as measured with a Klein K10-A colorimeter and patterns from the DisplayMate HDTV diagnostic suite. The resulting 25,802:1 contrast ratio is very good for a budget HDTV and rivals some of the more expensive models, including the Sunbrite 5560 HD (32,881:1). The lofty contrast ratio provided excellent shadow detail in the Ocean Deep episode of the BBC's Planet Earth on Blu-ray, particularly in the darker underwater sequences. ?
However, color accuracy wasn't quite up to par. As shown in the CIE color chart above, reds were pretty close to perfect but greens and blues were oversaturated (the closer each dot is to its corresponding box the more accurate the color). The heavy colors didn't present a serious tinting issue but the picture ran a little cool.
I observed minor backlight blooming from time to time but not to the point of distraction and only against a very dark background. The panel's 120Hz refresh rate provided smooth motion handling while I watched NBA basketball and PGA golf on ESPN. Off-axis viewing was good for a budget-class HDTV; the screen remained bright from any angle and image detail stayed sharp.
The E60 consumed 126 watts of power during testing while set to standard mode. In cinema mode that number dropped to 76 watts. Better yet, enabling Eco mode reduced power usage to just 57 watts without causing the picture to appear too dim. That's more energy efficient than the slightly smaller LG 55LM6700 (67 watts).
Conclusion
The Panasonic TC-LE60 series has a lot going for it. For just under $1,500, you get a bright 58-inch LED backlit screen that delivers a high contrast ratio and wide viewing angles. It also offers a solid feature set including wired and wireless Ethernet, numerous Web services, and a 120Hz refresh rate. It does exhibit a touch of backlight bloom, however, and its out of the box color accuracy is not ideal; calibrating the panel would likely resolve the latter. This set is a good option for 2D, but if you're a fan of 3D content, consider our Editors' Choice for midrange HDTVs, the 55-inch Panasonic TC-L55ET60. It'll cost you a couple of hundred dollars more and is a bit smaller than the TC-L58E60, but it comes with two sets of 3D glasses and is a solid performer.
Source: http://feedproxy.google.com/~r/ziffdavis/pcmag/~3/NpXJ1G3D25c/0,2817,2419533,00.asp
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May 28, 2013 ? A new study on prostate cancer describes a novel class of drugs developed by UT Southwestern Medical Center researchers that interrupts critical signaling needed for prostate cancer cells to grow.
In men with advanced prostate cancer, growth of cancer cells depends on androgen receptor signaling, which is driven by androgens, such as testosterone. To thwart tumor growth, most patients with advanced prostate cancer receive drugs that block the production of androgen or block the receptor where the androgen binds. Unfortunately, such treatments invariably fail and patients die of prostate cancer with their androgen receptor signaling still active and still promoting tumor growth.
In the new study, available online at Nature Communications, a team of researchers led by Dr. Ganesh Raj, associate professor of urology at UT Southwestern, found that they could disrupt androgen receptor signaling using a novel class of drugs called peptidomimetics. This therapeutic agent consists of an engineered small protein-like chain designed to mimic peptides that are critical for androgen receptor function. The peptidomimetic agents block the activity of the androgen receptor even in the presence of androgen by attacking the protein in a different spot from where the androgen binds.
"We are hopeful that this novel class of drugs will shut down androgen receptor signaling and lead to added options and increased longevity for men with advanced prostate cancer," said Dr. Raj, the senior author of the study.
Dr. Raj compared the action that takes place to a lock and key mechanism. In prostate cancer, the androgen receptor (lock) is activated by the androgen (key) resulting in a signal that causes prostate cancer proliferation. In advanced prostate cancer, despite drugs targeting either the lock (androgen receptor) or the key (androgen production), there can be aberrant keys that open the lock or mutated locks that are always open, resulting in cancer cell proliferation. Instead of trying to block the lock or the key, peptidomimetics uncouple the lock and key mechanism from the proliferation signal. Thus, even with the androgen receptor activated, the prostate cancer cells do not receive the signal to proliferate and do not grow.
The researchers tested their drug in mouse and human tissue models. The novel drug proved non-toxic and prevented androgen receptor signaling in cancer cells. The response is highly promising and suggests that peptidomimetic targeting of prostate cancer may be a viable therapeutic approach for men with advanced disease.
Further testing is needed before a drug could move to Phase 1 clinical trials that involve human participants.
"Most drugs now available to treat advanced prostate cancer improve survival rates by three or four months," Dr. Raj said. "Our new agents may offer hope for men who fail with the current drugs."
These findings represent the development of a first-in-class agent targeting critical interactions between proteins. Other cellular and disease processes eventually could also be targeted with peptidomimetics, the scientists said.
Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/dhDY2E9EThE/130528122514.htm
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A little added interactiveness with living room essentials goes a long way. With that in mind, Comcast today announced it's boosting its iOS X1 remote control with newly minted voice commands, something the company's been working on since earlier this year. Xfinity TV subscribers using the X1 platform will now be able to search for content by (quietly) shouting different vocal orders at the application, including, but not limited to, things like "Record," "Watch Gossip Girl" or "Find the Yankees game." While the new feature is only available on iOS at the moment, Comcast says its devs and engineers are "also working on voice control features for Android phones and for traditional remote controls." The X1 app update doesn't appear to be live just yet, but be sure to keep an eye on the App Store as it should be arriving pretty soon.
Filed under: Home Entertainment, Software, HD
Source: App Store
Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/bjHocwb_mDU/
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TUNIS, Tunisia (AP) ? Officials say streets vendors have clashed with police enforcing new regulations in a Tunisian town, and one local resident was killed and 17 police officers were wounded.
When police late Monday attempted to dismantle stalls and move the street vendors to a designated area, they rioted, setting fires and hurling stones at police who responded with tear gas.
It was the worst clash of its kind since earlier this year when police began curbing the proliferation of street vendors across the country.
The Bizerte hospital, north of the capital, Tunis, could not confirm the cause of the elderly man's death Tuesday morning. Radio reported it was tear gas inhalation.
Tunisia's 2011 uprising against the dictatorship was sparked by the self-immolation of a frustrated street vendor.
Source: http://news.yahoo.com/70-old-tunisian-dies-during-vendor-crackdown-152826562.html
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By Sarah N. Lynch
WASHINGTON (Reuters) - Nasdaq OMX on Wednesday agreed to pay $10 million, the largest penalty ever levied against a stock exchange, to settle civil charges stemming from mistakes made during Facebook's initial public offering last year, U.S. securities regulators said on Wednesday.
In its administrative proceeding against the stock exchange operator, the U.S. Securities and Exchange Commission said Nasdaq's "ill-fated decisions" on the day of the IPO led to a series of regulatory violations.
The SEC said Nasdaq's senior executives were aware of technical problems but decided to open up Facebook stock for secondary trading without first getting to the root cause of the troubles.
After trading had opened to the wider marketplace, the problems persisted. The exchange's chief economist spotted discrepancies in trading volume, and complaints from market makers started to mount. Still, exchange management decided not to halt trading, the SEC said.
As a result of those poor decisions, more than 30,000 Facebook orders remained stuck in Nasdaq's system for more than two hours when they should have been either executed or canceled. Investors were left in the lurch and market makers lost an estimated $500 million.
"This action against Nasdaq tells the tale of how poorly designed systems and hasty decision-making not only disrupted one of the largest IPOs in history, but produced serious and pervasive violations of fundamental rules governing our markets," said George Canellos, co-director of the SEC's enforcement division.
The exchange operator agreed to settle the charges without admitting or denying the allegations.
Separately, the exchange has agreed to pay as much as $62 million to compensate market makers for losses, an agreement approved by the SEC earlier this year.
Wednesday's settlement marks a major step for Nasdaq as it seeks to put the fallout from the Facebook debacle behind it. The exchange is still facing lingering battles with market markers who lost money in the May 18, 2012, IPO.
UBS, which lost $300 million - by far the most of any market player - is in arbitration with Nasdaq in an effort to recoup more money. A representative of UBS declined to comment on the status of the arbitration.
The SEC's case is the latest in a continuing crackdown on stock exchanges. Regulators are using enforcement as a tool to get exchanges to beef up their compliance with regulations and make sure they are properly self-policing.
Last year, the New York Stock Exchange became the first exchange in SEC history to face a financial penalty after it was accused of giving certain customers an "improper head start" on trading information.
In 2011 the SEC sanctioned Direct Edge for weak controls, and earlier this month the Chicago Board Options Exchange said it expects to be fined as much as $10 million to resolve an SEC probe into its duties as a self-policing organization.
In an open letter issued on Wednesday, Nasdaq CEO Robert Greifeld said the challenges that the exchange faced when the Facebook stock debuted were unprecedented.
"In the last year, we have carefully reviewed these events," Greifeld wrote. "As market leaders, we view our experiences as opportunities to learn and improve."
Facebook's IPO, the largest ever in terms of volume, was a much anticipated event. But the hype soon turned into panic after a software error at Nasdaq led to a 30-minute delay in the IPO.
The SEC said Nasdaq's senior management thought they had fixed the systems problem after removing a few lines of computer code and decided not to delay the start of secondary market trading.
But the technical problems persisted, with many brokers waiting for more than two hours to hear about the status of their orders.
In addition to charges stemming from poor decision-making, the SEC also said it was charging Nasdaq with a series of technical rule violations.
Nasdaq assumed a short position of more than 3 million shares of Facebook in an unauthorized account and covered that short position for a $10.8 million profit, two violations of exchange rules, the SEC said.
The agency also said it had found other problems unrelated to Facebook involving additional technology glitches. In those cases, in October 2011 and August 2012, the glitches led the exchange to violate rules that require investors to get the best bids and prices, the SEC said.
The settlement requires the exchange to make certain technical fixes related to its matching system for buy and sell orders for IPOs.
It also must expand the scope of its regulatory group's coverage of the rules governing its trading platforms and get the group more involved in decisions about software changes.
In his open letter, Greifeld said Nasdaq has already put new safeguards in place.
He said many of the SEC's demands have already been met, but he expects all of the requirements to be completed by the end of the year.
(Reporting by Sarah N. Lynch; Additional reporting by John McCrank in New York; Editing by Kenneth Barry and John Wallace)
Source: http://news.yahoo.com/nasdaq-pay-10-million-settle-sec-charges-facebook-162343558.html
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Clinton (AP/File)
Ready for Hillary, a super PAC supporting a possible Hillary Clinton presidential bid in 2016, announced Tuesday that longtime Clinton fundraiser Susie Tompkins Buell and Houston lawyers Steve Mostyn and Amber Mostyn would lead the organization?s national finance committee.
The addition of high-profile fundraising talent is the latest sign of the group?s seriousness and depth of connection to the former secretary of state as she weighs a potential candidacy.
?Hillary is the best candidate to build on the progress President Obama has made, and Ready for Hillary is the best vehicle for donors who want to help make Hillary our next president,? Steve Mostyn said in a statement released Wednesday. Mostyn and his wife contributed $3 million to the Obama-affiliated Priorities USA in 2012.
While Clinton has yet to offer any real indication of her intentions regarding the 2016 contest, Ready for Hillary has moved forcefully to recruit top talent since its launch earlier this year. The group was founded by George Washington University professor Allida Black and Adam Parkhomenco, who worked as a staffer on Clinton?s ill-fated 2008 presidential campaign.
Ready for Hillary received much attention early last month when James Carville, a Democratic strategist who helped engineer Bill Clinton?s winning 1992 campaign, announced he's backing the group. In an email blast, Carville wrote, ?We owe it to Hillary to start putting the building blocks of her campaign together now. The modern political campaign demands it.?
Carville?s support mirrors that of many other Clinton family surrogates who have stepped forward in recent months to be part of the Ready for Hillary team. Craig Smith, who recently assumed a senior leadership role with the PAC, served as political director in the Clinton White House; Harold Ickes, another longtime adviser to Bill Clinton, is supporting the group as well.
Buell, who refrained from opening up her wallet for President Obama in the last two election cycles, led Hillary?s fundraising efforts in the San Francisco Bay Area in 2008. ?Ready for Hillary is the wisest investment right now for anyone who wants Hillary Clinton to be the next president,? Buell said in a statement.
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May 28, 2013 ? Some people seem to pick up a second language with relative ease, while others have a much more difficult time. Now, a new study suggests that learning to understand and read a second language may be driven, at least in part, by our ability to pick up on statistical regularities.
The study is published in Psychological Science, a journal of the Association for Psychological Science.
Some research suggests that learning a second language draws on capacities that are language-specific, while other research suggests that it reflects a more general capacity for learning patterns. According to psychological scientist and lead researcher Ram Frost of Hebrew University, the data from the new study clearly point to the latter:
"These new results suggest that learning a second language is determined to a large extent by an individual ability that is not at all linguistic," says Frost.
In the study, Frost and colleagues used three different tasks to measure how well American students in an overseas program picked up on the structure of words and sounds in Hebrew. The students were tested once in the first semester and again in the second semester.
The students also completed a task that measured their ability to pick up on statistical patterns in visual stimuli. The participants watched a stream of complex shapes that were presented one at a time. Unbeknownst to the participants, the 24 shapes were organized into 8 triplets -- the order of the triplets was randomized, though the shapes within each triplet always appeared in the same sequence. After viewing the stream of shapes, the students were tested to see whether they implicitly picked up the statistical regularities of the shape sequences.
The data revealed a strong association between statistical learning and language learning: Students who were high performers on the shapes task tended to pick up the most Hebrew over the two semesters.
"It's surprising that a short 15-minute test involving the perception of visual shapes could predict to such a large extent which of the students who came to study Hebrew would finish the year with a better grasp of the language," says Frost.
According to the researchers, establishing a link between second language acquisition and a general capacity for statistical learning may have broad implications.
"This finding points to the possibility that a unified and universal principle of statistical learning can quantitatively explain a wide range of cognitive processes across domains, whether they are linguistic or nonlinguistic," they conclude.
This research was supported by the Israel Science Foundation (159/10) and by the National Institute of Child Health and Human Development (RO1 HD 067364 and PO1HD 01994).
Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/JkYFOUSJm24/130528143800.htm
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A family practice doctor in Maine is refusing all forms of health insurance, including Medicare, in order, he says, to provide better service to his patients. Dr. Michael Ciampi told the Bangor Daily News that he wants to practice medicine without being dictated to by insurance companies. On April 1, Ciampi lowered his prices and [...]
Source: http://news.yahoo.com/hbos-behind-candelabra-premiere-draws-2-4-million-005324912.html
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NEW YORK (AP) ? The founder of an online currency transfer business was indicted in the United States along with six other people in a $6 billion money-laundering scheme described as "staggering" in its scope, authorities said Tuesday.
Arthur Budovsky is the founder of Liberty Reserve, a Costa Rica-based website long favored by cybercrime scammers. He was arrested in Spain on Friday. A defendant identified as Budovsky's partner, Vladimir Kats, was in custody in New York.
Authorities say the network processed at least 55 million illegal transactions worldwide for 1 million users, including 200,000 in the United States. They call the international money-laundering case the largest ever.
"The scope of the defendants' unlawful conduct is staggering," said an indictment unsealed in federal court in Manhattan. In announcing the case, U.S. Attorney Preet Bharara said the network "became the bank of choice for the criminal underworld."
Its digital currency service was designed to shield the identity of crooked users seeking to launder ill-gotten gains, he said.
"The coin of the realm was anonymity," he said. "It was the opposite of a know-your-customer policy."
In a statement, Costa Rica police confirmed that Budovsky had been arrested in Spain on money laundering charges and that several premises linked to his company had been raided. A notice pasted across Liberty Reserve's website Tuesday morning said the domain "has been seized by the United States Global Illicit Financial Team."
Attempts to reach Liberty Reserve by phone and email were not immediately successful.
Its demise is likely to send a sharp shock across the Internet.
The indictment calls the network "one of the principal means by which cyber criminals around the world distribute, store and launder proceeds of their illegal activity ... including credit card fraud, identity theft, investment fraud, computer hacking, child pornography and narcotics trafficking."
Liberty Reserve allowed users to open accounts using fictitious names, including "Russian Hacker" and "Hacker Account." The network charged a 1 percent fee on transactions.
Budovsky and Katz have previous convictions on charges related to an unlicensed money-transmitting business, according to court papers. After that case, the pair decided to move their operation to Costa Rica, where Budovsky officially renounced his U.S. citizenship, the papers say.
In an online chat captured by law enforcement, Katz admitted Liberty Reserve was "illegal" and noted that authorities in the United States knew it was "a money laundering operation that hackers use."
Aditya Sood, a computer science doctoral candidate at Michigan State University who has studied the underground economy, described Liberty Reserve as a no-questions-asked alternative to the global banking system, with little more than a valid email needed to open an account and start moving money across borders.
"You don't need to provide your full details, or personal information, or things like that," Sood said in a telephone interview. "There's no way to trace an account. That's the beauty of the system."
Budovsky and another man identified by Spanish authorities as Azzeddine el Amine were arrested Friday at Madrid's Barajas airport while trying to catch a connecting flight from Morocco to Costa Rica, according to a Spanish National Court official, who spoke on condition of anonymity because court policy forbids him from speaking on the record.
Both men have indicated they will fight any move to send them to the U.S., the official said. The pair were ordered to remain in prison pending an extradition hearing.
Authorities described Liberty Reserve as being rife with criminals, but the site's ease of use, low fees and irreversible transactions that deterred fraud also attracted a thriving community of legitimate tech-savvy users in countries with limited access to credit cards.
Mitchell Rossetti, whose Houston, Texas-based ePayCards.com was one of several mainstream merchants that accepted the online-only currency, said his business still had about $28,000 tied up in Liberty Reserve accounts.
"The irony of this is I went to them because of the security," Rossetti said. "All sales were final."
He acknowledged that the currency was being used by scammers, but said Liberty Reserve was just like any other currency. "The U.S. dollar can be donated to a church or it can pay a prostitute," he said.
Liberty Reserve appears to have played an important role in laundering the proceeds from the recent theft of some $45 million from two Middle Eastern banks, according to legal documents made public by U.S. authorities earlier this month.
The complaint against one of the Dominican Republic gang members allegedly involved in the theft states that thousands of dollars' worth of stolen cash was deposited into two Liberty Reserve accounts via currency centers based in Siberia and Singapore.
A total of 14 premises were raised in Panama, Switzerland, the U.S., Sweden, and Costa Rica, according to Spanish authorities. In Costa Rica, investigators recovered five luxury cars, including three Rolls Royces, Spanish police said. Bharara, the federal prosecutor, said authorities had seized Liberty's computer servers in Costa Rica and Switzerland.
___
Satter reported from London. Alan Clendenning and Jorge Sainz in Madrid contributed to this report.
Source: http://news.yahoo.com/ny-indictment-filed-6b-money-laundering-case-174401456.html
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LONDON (AP) ? British police arrested a 10th suspect Monday in connection with the vicious street killing of a soldier in London, an apparent Islamic extremist attack that has horrified the country and heightened racial tensions.
The 50-year-old man was detained in Welling, east of London, on suspicion of conspiring to murder 25-year-old soldier Lee Rigby, Scotland Yard said. Police gave no further information about the suspect's identity.
The latest arrest came as more details trickled out about the background of Michael Adebolajo, 28, one of the two main British suspects in Wednesday's slaying. He and Michael Adebowale, 22, were shot and wounded by police at the scene.
Rigby, an off-duty soldier who had served in Afghanistan, was run over by a vehicle and repeatedly attacked with meat cleavers Wednesday afternoon near his barracks in southeast London.
British officials say the two main suspects had been known to them for some time, but revelations that Adebolajo had been arrested in Kenya in 2010 ? and claims that British security officials had tried to recruit him as an informer after that ? have fueled questions about whether U.K. authorities could have done more to prevent last week's killing.
Adebolajo and Adebowale remain under armed guard in separate London hospitals. Four other men and the suspect arrested Monday remain in custody at a London police station, while one other man has been released on bail. Two women were released without charge in the case.
On Monday, a London-based rights group that lobbies on behalf of suspected terrorists said Adebolajo and his family had contacted it about six months ago complaining about harassment from Britain's MI5 domestic spy service. A case worker who spoke with him said he appeared "paranoid and erratic," the group said.
"His sister contacted the office to complain about constant harassment from MI5, which extended to Michael, his brother, and his father also," said Moazzam Begg of the London-based group CagePrisoners.
"They were all being approached in different ways," Begg told The Associated Press in a telephone interview. "One of them, he lived and worked abroad. He'd been approached by MI6 (Britain's external espionage agency) at his workplace and had been offered some money. They wanted him to work for them."
Begg said Adebolajo told the caseworker he had been tortured and threatened with rape while in Kenya, and that he had been interrogated for several hours upon his return to London. At first, British intelligence services let him be, Begg said, but in March 2012 they met with him and offered him a job as an informant. Adebolajo refused, he said.
Kenyan officials on Sunday said Adebolajo was arrested in Kenya in 2010 with five others near the country's border with Somalia. Police believed that Adebolajo was going to work with the Somali Islamic militant group al-Shabab.
Kenyan government spokesman Muthui Kariuki told the AP that Adebolajo, who was carrying a British passport, was taken to court before he was handed over to British authorities in Kenya.
Britain's Foreign Office confirmed that Adebolajo was arrested in Kenya in 2010 and said the agency "provided consular assistance."
It was not clear how Adebolajo came to be arrested and how he returned to London. Kenyan officials have denied allegations that he was tortured under interrogation. On Monday, Kenya's police chief David Kimaiyo added confusion by contradicting earlier claims and saying that Adebolajo had "never been arrested in Kenya."
Earlier, hardline Muslim leaders described Adebolajo as a British citizen of Nigerian descent who converted to Islam and attended demonstrations and lectures organized by British radical group al-Muhajiroun.
Rigby's killing and Adebolajo's apparent links to radical Islam have fed a spike in anti-Muslim sentiment in Britain, with police and activists reporting a surge in hate crimes, violence and vandalism.
Around 1,000 supporters of the far-right group English Defense League marched through central London on Monday to protest the soldier's killing, clashing with a smaller group of anti-fascist demonstrators and scuffling with riot police. Police arrested 13 people, mostly on suspicion of causing public disorder.
A mosque in the northern England town of Grimsby was firebombed Sunday night, according to the mosque's chairman, Diler Gharib. Police said they arrested two people and the fire was extinguished without injuries.
In the West Midlands, police charged two people with racially aggravated public order offenses following a weekend protest.
___
Associated Press writer Raphael Satter in London and Tom Odula in Nairobi, Kenya, contributed to this report.
Source: http://news.yahoo.com/uk-police-arrest-10th-suspect-soldiers-slaying-153409017.html
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LG has finally confirmed that it's making a white version of the Nexus 4?but it's also admitted that it's not interested in manufacturing another Google phone.
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By Jeff Mason
ARLINGTON, Virginia (Reuters) - President Barack Obama paid tribute on Monday to fallen men and women of the U.S. armed services during a Memorial Day ceremony in which he reminded Americans that the country was still at war.
During a solemn visit to Arlington National Ceremony, the resting ground for many military casualties, Obama noted in remarks to visitors that next year would mark the last Memorial Day of the U.S. war in Afghanistan.
"But even as we turn the page on a decade of conflict, even as we look forward, let us never forget, as we gather here today, that our nation is still at war," Obama said.
Unlike World War Two or the Vietnam War, conflicts that touched nearly every American, today most U.S. citizens were not directly affected by the military conflicts overseas, the president noted.
"As we gather here today, at this very moment, more than 60,000 of our fellow Americans still serve far from home in Afghanistan," Obama said.
"They're still going out on patrol, still living in spartan forward operating bases, still risking their lives to carry out their mission. And when they give their lives, they are still being laid to rest in cemeteries in the quiet corners across our country, including here in Arlington."
Most U.S. combat troops are slated to exit Afghanistan by the end of 2014. Obama formally ended the U.S. war in Iraq earlier in his White House tenure.
In a major policy speech last week, Obama said the United States would shift its focus away from a "boundless global war on terror" that began under his predecessor, Republican President George W. Bush.
After his remarks on Monday, Obama and his wife, first lady Michelle Obama, visited Section 60 of the cemetery, where the newly slain are buried.
"Today, just steps from where these brave Americans lie in eternal peace, we declare, as a proud and grateful nation, that their sacrifice will never be forgotten," Obama said.
"And just as we honor them, we hold their families close. Because for the parents who lose a child; for the husbands and wives who lose a partner; for the children who lose a parent, every loss is devastating. And for those of us who bear the solemn responsibility of sending these men and women into harm's way, we know the consequences all too well."
The first lady has made helping military families one of her primary causes, along with fighting childhood obesity.
During the ceremony, Michelle Obama leaned forward to watch as an Air Force singer delivered a powerful rendition of "America the Beautiful."
Earlier, the president laid a wreath at the Tomb of the Unknown Soldier, placing his hand over his heart while taps was played.
Entering and exiting the cemetery, Obama's motorcade snaked down a street lined with uniformed military members while the boom of a ceremonial canon sounded off in the background. It passed rows of white gravestones with small American flags planted beside them, along with onlookers and family members who had come to visit fallen loved ones.
(Editing by Philip Barbara)
Source: http://news.yahoo.com/memorial-day-obama-pays-tribute-fallen-175529828.html
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According to Senator Robert Menendez (D-NJ), immigration reform currently doesn?t have 60 votes in the Senate, but the good news is many Republicans are trying to find a compromise they can support instead of simply trying to kill any reform. Last week Orrin Hatch (R-UT) backed the bill in committee after getting his fingerprinting amendment added. On This Week yesterday, Senator Rand Paul (R-KY) said he might be able to support immigration reform if some changes are made. From This Week:
[Martha] RADDATZ: But let ? let?s move to immigration. Would you support the bill, the Senate bill that made it through committee this week?
[RON] PAUL: I support immigration reform. At this time, I think the bill needs to strengthen border security. It also needs to expand work visas. The main problem with illegal immigration is that we don?t have enough legal immigration. This bill, because it was negotiated with the unions, actually lowers the numbers for work visas. That?s exactly the wrong direction to go. So I will support a bill that fixes it, and I do want to support a bill. I?ve talked to the authors of it. If they work with me on my amendment, which is called Trust But Verify, there is a very good chance I can vote for it. But it has to be a better bill.
Senate Republicans are slowly coming on board but while moving the legislation rightward. The original Gang of Eight proposal is going to serve as the leftward edge in this debate. The bill moved to the right in committee, will likely moving further to the right on the Senate floor, and is almost assured to become significantly more conservative when it reaches the House.
Photo by Gage Skidmore released under Creative Commons License
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