Panasonic TC-L58E60

With Panasonic's new Viera E60 family of connected LED-backlit HDTVs you get many of the features found on high-end models at a price that won't strain your budget. The TC-L58E60 reviewed here carries a list price of $1,499.99 and features a large 58-inch screen with a 120Hz refresh rate, wired and wireless networking, a good selection of Web services, and a streamlined cabinet design. But it's not without flaws; greens and blues are oversaturated and there are traces of blooming when the background is dark.

Design and Features
As with the Editors' Choice Panasonic TC-L55ET60, the TC-L58E60's cabinet is stylishly thin (1.4 inches) and is ably supported by a rigid rectangular stand. The 1,920-by-1,080-pixel panel is framed by razor-thin black bezels on all sides, and there's a strip of clear plastic beneath the bottom bezel that holds an ambient light sensor, a remote sensor, and a power indicator.

The TC-L58E60 only has three HDMI ports, whereas most big-screen TVs offer at least four, and sometimes five. They are mounted at the rear of the cabinet facing outward along with a set of shared component and composite AV jacks, an Ethernet port, a digital audio output, and a cable/antenna jack. Two USB ports are close by, facing left.?A set of basic controls sit on the right edge of the screen.

In addition to wired Ethernet the E60 offers built-in Wi-Fi. Web services are plentiful and include streaming apps from Netflix, Amazon Instant Video, Hulu Plus, YouTube, and CinemaNow. Social networking apps, including Skype, Facebook, and Twitter, are also part of the package, as are a handful of Playjam games and Panasonic's own Viera Connect Market shopping service.

The E60 uses the same remote as the ET60 with one exception; a sleep button takes the place of a 3D button (this set is not 3D-capable). The matte black wand is 8.5 inches long and has 43 buttons, four arrow keys, an Apps button, and a dedicated Netflix button. The Home button brings you to the My Home screen where you can create customized menus for each member of the family by populating it with their favorite apps and photo, video, and music selections.

The basic picture settings menu offers the usual brightness, contrast, color temperature, tint, and backlight adjustments as well as Vivid Color (enhanced greens and blues), A.I. Picture (enhances dark areas without changing black level or brightness), and five picture presets (Vivid, Standard, Home Theater, Cinema, and Custom). The Pro settings menu lets you adjust black level gradation, fine tune white point levels in reds, greens, and blues, tweak RGB hue, saturation, and luminance levels, and adjust gamma settings. Advanced settings include an optimized game mode, 3:2 pulldown (reduces judder in film-based content), light and dark black levels, and HDMI range settings.

The TC-L58E60 comes with a standard one-year warranty that can be extended to three years for an additional $129.99, or to four years for an additional $169.99.

Performance
The TC-L58E60 performed well on some tests and not so well on others. It produced a nice peak brightness of 353.50 cd/m² and a solid black level reading of 0.0137 cd/m² as measured with a Klein K10-A colorimeter and patterns from the DisplayMate HDTV diagnostic suite. The resulting 25,802:1 contrast ratio is very good for a budget HDTV and rivals some of the more expensive models, including the Sunbrite 5560 HD (32,881:1). The lofty contrast ratio provided excellent shadow detail in the Ocean Deep episode of the BBC's Planet Earth on Blu-ray, particularly in the darker underwater sequences. ?

However, color accuracy wasn't quite up to par. As shown in the CIE color chart above, reds were pretty close to perfect but greens and blues were oversaturated (the closer each dot is to its corresponding box the more accurate the color). The heavy colors didn't present a serious tinting issue but the picture ran a little cool.

I observed minor backlight blooming from time to time but not to the point of distraction and only against a very dark background. The panel's 120Hz refresh rate provided smooth motion handling while I watched NBA basketball and PGA golf on ESPN. Off-axis viewing was good for a budget-class HDTV; the screen remained bright from any angle and image detail stayed sharp.

The E60 consumed 126 watts of power during testing while set to standard mode. In cinema mode that number dropped to 76 watts. Better yet, enabling Eco mode reduced power usage to just 57 watts without causing the picture to appear too dim. That's more energy efficient than the slightly smaller LG 55LM6700 (67 watts).

Conclusion
The Panasonic TC-LE60 series has a lot going for it. For just under $1,500, you get a bright 58-inch LED backlit screen that delivers a high contrast ratio and wide viewing angles. It also offers a solid feature set including wired and wireless Ethernet, numerous Web services, and a 120Hz refresh rate. It does exhibit a touch of backlight bloom, however, and its out of the box color accuracy is not ideal; calibrating the panel would likely resolve the latter. This set is a good option for 2D, but if you're a fan of 3D content, consider our Editors' Choice for midrange HDTVs, the 55-inch Panasonic TC-L55ET60. It'll cost you a couple of hundred dollars more and is a bit smaller than the TC-L58E60, but it comes with two sets of 3D glasses and is a solid performer.

Source: http://feedproxy.google.com/~r/ziffdavis/pcmag/~3/NpXJ1G3D25c/0,2817,2419533,00.asp

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Novel class of drugs for prostate cancers

May 28, 2013 ? A new study on prostate cancer describes a novel class of drugs developed by UT Southwestern Medical Center researchers that interrupts critical signaling needed for prostate cancer cells to grow.

In men with advanced prostate cancer, growth of cancer cells depends on androgen receptor signaling, which is driven by androgens, such as testosterone. To thwart tumor growth, most patients with advanced prostate cancer receive drugs that block the production of androgen or block the receptor where the androgen binds. Unfortunately, such treatments invariably fail and patients die of prostate cancer with their androgen receptor signaling still active and still promoting tumor growth.

In the new study, available online at Nature Communications, a team of researchers led by Dr. Ganesh Raj, associate professor of urology at UT Southwestern, found that they could disrupt androgen receptor signaling using a novel class of drugs called peptidomimetics. This therapeutic agent consists of an engineered small protein-like chain designed to mimic peptides that are critical for androgen receptor function. The peptidomimetic agents block the activity of the androgen receptor even in the presence of androgen by attacking the protein in a different spot from where the androgen binds.

"We are hopeful that this novel class of drugs will shut down androgen receptor signaling and lead to added options and increased longevity for men with advanced prostate cancer," said Dr. Raj, the senior author of the study.

Dr. Raj compared the action that takes place to a lock and key mechanism. In prostate cancer, the androgen receptor (lock) is activated by the androgen (key) resulting in a signal that causes prostate cancer proliferation. In advanced prostate cancer, despite drugs targeting either the lock (androgen receptor) or the key (androgen production), there can be aberrant keys that open the lock or mutated locks that are always open, resulting in cancer cell proliferation. Instead of trying to block the lock or the key, peptidomimetics uncouple the lock and key mechanism from the proliferation signal. Thus, even with the androgen receptor activated, the prostate cancer cells do not receive the signal to proliferate and do not grow.

The researchers tested their drug in mouse and human tissue models. The novel drug proved non-toxic and prevented androgen receptor signaling in cancer cells. The response is highly promising and suggests that peptidomimetic targeting of prostate cancer may be a viable therapeutic approach for men with advanced disease.

Further testing is needed before a drug could move to Phase 1 clinical trials that involve human participants.

"Most drugs now available to treat advanced prostate cancer improve survival rates by three or four months," Dr. Raj said. "Our new agents may offer hope for men who fail with the current drugs."

These findings represent the development of a first-in-class agent targeting critical interactions between proteins. Other cellular and disease processes eventually could also be targeted with peptidomimetics, the scientists said.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/dhDY2E9EThE/130528122514.htm

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Comcast's X1 remote app gains voice commands on iOS, Android update in the works

A little added interactiveness with living room essentials goes a long way. With that in mind, Comcast today announced it's boosting its iOS X1 remote control with newly minted voice commands, something the company's been working on since earlier this year. Xfinity TV subscribers using the X1 platform will now be able to search for content by (quietly) shouting different vocal orders at the application, including, but not limited to, things like "Record," "Watch Gossip Girl" or "Find the Yankees game." While the new feature is only available on iOS at the moment, Comcast says its devs and engineers are "also working on voice control features for Android phones and for traditional remote controls." The X1 app update doesn't appear to be live just yet, but be sure to keep an eye on the App Store as it should be arriving pretty soon.

Filed under: Home Entertainment, Software, HD

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Source: App Store

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/bjHocwb_mDU/

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70-year-old Tunisian dies during vendor crackdown

TUNIS, Tunisia (AP) ? Officials say streets vendors have clashed with police enforcing new regulations in a Tunisian town, and one local resident was killed and 17 police officers were wounded.

When police late Monday attempted to dismantle stalls and move the street vendors to a designated area, they rioted, setting fires and hurling stones at police who responded with tear gas.

It was the worst clash of its kind since earlier this year when police began curbing the proliferation of street vendors across the country.

The Bizerte hospital, north of the capital, Tunis, could not confirm the cause of the elderly man's death Tuesday morning. Radio reported it was tear gas inhalation.

Tunisia's 2011 uprising against the dictatorship was sparked by the self-immolation of a frustrated street vendor.

Source: http://news.yahoo.com/70-old-tunisian-dies-during-vendor-crackdown-152826562.html

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Nasdaq to pay $10 million to settle SEC charges from Facebook snafu

By Sarah N. Lynch

WASHINGTON (Reuters) - Nasdaq OMX on Wednesday agreed to pay $10 million, the largest penalty ever levied against a stock exchange, to settle civil charges stemming from mistakes made during Facebook's initial public offering last year, U.S. securities regulators said on Wednesday.

In its administrative proceeding against the stock exchange operator, the U.S. Securities and Exchange Commission said Nasdaq's "ill-fated decisions" on the day of the IPO led to a series of regulatory violations.

The SEC said Nasdaq's senior executives were aware of technical problems but decided to open up Facebook stock for secondary trading without first getting to the root cause of the troubles.

After trading had opened to the wider marketplace, the problems persisted. The exchange's chief economist spotted discrepancies in trading volume, and complaints from market makers started to mount. Still, exchange management decided not to halt trading, the SEC said.

As a result of those poor decisions, more than 30,000 Facebook orders remained stuck in Nasdaq's system for more than two hours when they should have been either executed or canceled. Investors were left in the lurch and market makers lost an estimated $500 million.

"This action against Nasdaq tells the tale of how poorly designed systems and hasty decision-making not only disrupted one of the largest IPOs in history, but produced serious and pervasive violations of fundamental rules governing our markets," said George Canellos, co-director of the SEC's enforcement division.

The exchange operator agreed to settle the charges without admitting or denying the allegations.

Separately, the exchange has agreed to pay as much as $62 million to compensate market makers for losses, an agreement approved by the SEC earlier this year.

Wednesday's settlement marks a major step for Nasdaq as it seeks to put the fallout from the Facebook debacle behind it. The exchange is still facing lingering battles with market markers who lost money in the May 18, 2012, IPO.

UBS, which lost $300 million - by far the most of any market player - is in arbitration with Nasdaq in an effort to recoup more money. A representative of UBS declined to comment on the status of the arbitration.

The SEC's case is the latest in a continuing crackdown on stock exchanges. Regulators are using enforcement as a tool to get exchanges to beef up their compliance with regulations and make sure they are properly self-policing.

Last year, the New York Stock Exchange became the first exchange in SEC history to face a financial penalty after it was accused of giving certain customers an "improper head start" on trading information.

In 2011 the SEC sanctioned Direct Edge for weak controls, and earlier this month the Chicago Board Options Exchange said it expects to be fined as much as $10 million to resolve an SEC probe into its duties as a self-policing organization.

In an open letter issued on Wednesday, Nasdaq CEO Robert Greifeld said the challenges that the exchange faced when the Facebook stock debuted were unprecedented.

"In the last year, we have carefully reviewed these events," Greifeld wrote. "As market leaders, we view our experiences as opportunities to learn and improve."

Facebook's IPO, the largest ever in terms of volume, was a much anticipated event. But the hype soon turned into panic after a software error at Nasdaq led to a 30-minute delay in the IPO.

The SEC said Nasdaq's senior management thought they had fixed the systems problem after removing a few lines of computer code and decided not to delay the start of secondary market trading.

But the technical problems persisted, with many brokers waiting for more than two hours to hear about the status of their orders.

In addition to charges stemming from poor decision-making, the SEC also said it was charging Nasdaq with a series of technical rule violations.

Nasdaq assumed a short position of more than 3 million shares of Facebook in an unauthorized account and covered that short position for a $10.8 million profit, two violations of exchange rules, the SEC said.

The agency also said it had found other problems unrelated to Facebook involving additional technology glitches. In those cases, in October 2011 and August 2012, the glitches led the exchange to violate rules that require investors to get the best bids and prices, the SEC said.

The settlement requires the exchange to make certain technical fixes related to its matching system for buy and sell orders for IPOs.

It also must expand the scope of its regulatory group's coverage of the rules governing its trading platforms and get the group more involved in decisions about software changes.

In his open letter, Greifeld said Nasdaq has already put new safeguards in place.

He said many of the SEC's demands have already been met, but he expects all of the requirements to be completed by the end of the year.

(Reporting by Sarah N. Lynch; Additional reporting by John McCrank in New York; Editing by Kenneth Barry and John Wallace)

Source: http://news.yahoo.com/nasdaq-pay-10-million-settle-sec-charges-facebook-162343558.html

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Super PAC supporting Clinton presidential bid names finance chairs

Clinton (AP/File)

Ready for Hillary, a super PAC supporting a possible Hillary Clinton presidential bid in 2016, announced Tuesday that longtime Clinton fundraiser Susie Tompkins Buell and Houston lawyers Steve Mostyn and Amber Mostyn would lead the organization?s national finance committee.

The addition of high-profile fundraising talent is the latest sign of the group?s seriousness and depth of connection to the former secretary of state as she weighs a potential candidacy.

?Hillary is the best candidate to build on the progress President Obama has made, and Ready for Hillary is the best vehicle for donors who want to help make Hillary our next president,? Steve Mostyn said in a statement released Wednesday. Mostyn and his wife contributed $3 million to the Obama-affiliated Priorities USA in 2012.

While Clinton has yet to offer any real indication of her intentions regarding the 2016 contest, Ready for Hillary has moved forcefully to recruit top talent since its launch earlier this year. The group was founded by George Washington University professor Allida Black and Adam Parkhomenco, who worked as a staffer on Clinton?s ill-fated 2008 presidential campaign.

Ready for Hillary received much attention early last month when James Carville, a Democratic strategist who helped engineer Bill Clinton?s winning 1992 campaign, announced he's backing the group. In an email blast, Carville wrote, ?We owe it to Hillary to start putting the building blocks of her campaign together now. The modern political campaign demands it.?

Carville?s support mirrors that of many other Clinton family surrogates who have stepped forward in recent months to be part of the Ready for Hillary team. Craig Smith, who recently assumed a senior leadership role with the PAC, served as political director in the Clinton White House; Harold Ickes, another longtime adviser to Bill Clinton, is supporting the group as well.

Buell, who refrained from opening up her wallet for President Obama in the last two election cycles, led Hillary?s fundraising efforts in the San Francisco Bay Area in 2008. ?Ready for Hillary is the wisest investment right now for anyone who wants Hillary Clinton to be the next president,? Buell said in a statement.

Source: http://news.yahoo.com/blogs/ticket/super-pac-supporting-clinton-presidential-bid-names-finance-214922520.html

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Picking up a second language is predicted by ability to learn patterns

May 28, 2013 ? Some people seem to pick up a second language with relative ease, while others have a much more difficult time. Now, a new study suggests that learning to understand and read a second language may be driven, at least in part, by our ability to pick up on statistical regularities.

The study is published in Psychological Science, a journal of the Association for Psychological Science.

Some research suggests that learning a second language draws on capacities that are language-specific, while other research suggests that it reflects a more general capacity for learning patterns. According to psychological scientist and lead researcher Ram Frost of Hebrew University, the data from the new study clearly point to the latter:

"These new results suggest that learning a second language is determined to a large extent by an individual ability that is not at all linguistic," says Frost.

In the study, Frost and colleagues used three different tasks to measure how well American students in an overseas program picked up on the structure of words and sounds in Hebrew. The students were tested once in the first semester and again in the second semester.

The students also completed a task that measured their ability to pick up on statistical patterns in visual stimuli. The participants watched a stream of complex shapes that were presented one at a time. Unbeknownst to the participants, the 24 shapes were organized into 8 triplets -- the order of the triplets was randomized, though the shapes within each triplet always appeared in the same sequence. After viewing the stream of shapes, the students were tested to see whether they implicitly picked up the statistical regularities of the shape sequences.

The data revealed a strong association between statistical learning and language learning: Students who were high performers on the shapes task tended to pick up the most Hebrew over the two semesters.

"It's surprising that a short 15-minute test involving the perception of visual shapes could predict to such a large extent which of the students who came to study Hebrew would finish the year with a better grasp of the language," says Frost.

According to the researchers, establishing a link between second language acquisition and a general capacity for statistical learning may have broad implications.

"This finding points to the possibility that a unified and universal principle of statistical learning can quantitatively explain a wide range of cognitive processes across domains, whether they are linguistic or nonlinguistic," they conclude.

This research was supported by the Israel Science Foundation (159/10) and by the National Institute of Child Health and Human Development (RO1 HD 067364 and PO1HD 01994).

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/JkYFOUSJm24/130528143800.htm

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